Predicting Multi-actor collaborations using Hypergraphs

Social networks are now ubiquitous and most of them contain interactions involving multiple actors (groups) like author collaborations, teams or emails in an organizations, etc. Hypergraphs are natural structures to effectively capture multi-actor interactions which conventional dyadic graphs fail to capture. In this work the problem of predicting collaborations is addressed while modeling the collaboration network as a hypergraph network. The problem of predicting future multi-actor collaboration is mapped to hyperedge prediction problem. Given that the higher order edge prediction is an inherently hard problem, in this work we restrict to the task of predicting edges (collaborations) that have already been observed in past. In this work, we propose a novel use of hyperincidence temporal tensors to capture time varying hypergraphs and provides a tensor decomposition based prediction algorithm. We quantitatively compare the performance of the hypergraphs based approach with the conventional dyadic graph based approach. Our hypothesis that hypergraphs preserve the information that simple graphs destroy is corroborated by experiments using author collaboration network from the DBLP dataset. Our results demonstrate the strength of hypergraph based approach to predict higher order collaborations (size>4) which is very difficult using dyadic graph based approach. Moreover, while predicting collaborations of size>2 hypergraphs in most cases provide better results with an average increase of approx. 45% in F-Score for different sizes = {3,4,5,6,7}

Guest Editorial

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Scientometrics of cereal crops research in India as reflected through Indian Science Abstracts and CAB Abstracts during 1965-2010

The paper analyses publication output of India on cereal crops as reflected by its coverage in Indian Science Abstracts (ISA) and CAB Abstracts during 1965-2010.The analysis indicates that highest number of papers (43.80%) was published on rice, followed by wheat (24.28%). Agricultural universities and institutions under aegis of Indian Council of Agricultural Research (ICAR) were most productive. Most of the papers were published in Indian journals with low impact factor. The highest number of papers was published in Indian Journal of Agricultural Sciences, followed by Indian Journal of Agronomy, Madras Agricultural Journaland Journal of Maharashtra Agricultural University. Indian Agricultural Research Institute, New Delhi,Tamil Nadu Agricultural University, Coimbatoreand Punjab Agricultural University, Ludhianacontributed about 7% of papers each. The major research was focused on ‘genetic and plant breeding’ (28.2%) followed by ‘agronomic aspects’ (27.9%) and pest, diseases and pest control (19.7%). The authorship pattern reveals that co-authored papers accounted for 90% of total output. Citation analysis of the study using Google scholar reveals that 57% of the papers remained uncited and 36.8% papersreceived citations ranging from 1 to 10.Highest number of citations were received by papers published in Indian Journal of Agronomy(1446), followed by Indian Journal of Agricultural Science (1211), Euphytica (1109) and Theoretical and Applied Genetics (1000

Id4 dependent acetylation restores mutant-p53 transcriptional activity

BACKGROUND: The mechanisms that can restore biological activity of mutant p53 are an area of high interest given that mutant p53 expression is observed in one third of prostate cancer. Here we demonstrate that Id4, an HLH transcriptional regulator and a tumor suppressor, can restore the mutant p53 transcriptional activity in prostate cancer cells. METHODS: Id4 was over-expressed in prostate cancer cell line DU145 harboring mutant p53 (P223L and V274F) and silenced in LNCaP cells with wild type p53. The cells were used to quantitate apoptosis, p53 localization, p53 DNA binding and transcriptional activity. Immuno-precipitation/-blot studies were performed to demonstrate interactions between Id4, p53 and CBP/p300 and acetylation of specific lysine residues within p53. RESULTS: Ectopic expression of Id4 in DU145 cells resulted in increased apoptosis and expression of BAX, PUMA and p21, the transcriptional targets of p53. Mutant p53 gained DNA binding and transcriptional activity in the presence of Id4 in DU145 cells. Conversely, loss of Id4 in LNCaP cells abrogated wild type p53 DNA binding and transactivation potential. Gain of Id4 resulted in increased acetylation of mutant p53 whereas loss of Id4 lead to decreased acetylation in DU145 and LNCaP cells respectively. Id4 dependent acetylation of p53 was in part due to a physical interaction between Id4, p53 and acetyl-transferase CBP/p300. CONCLUSIONS: Taken together, our results suggest that Id4 regulates the activity of wild type and mutant p53. Id4 promoted the assembly of a macromolecular complex involving CBP/P300 that resulted in acetylation of p53 at K373, a critical post-translational modification required for its biological activity

Id4 Deficiency Attenuates Prostate Development and Promotes PIN-like Lesions by Regulating Androgen Receptor Activity and Expression of NKX3.1 and PTEN

Background: Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. Id4 is expressed in the normal prostate where its expression is also regulated by androgens. In this study we investigated the effect of loss of Id4 (Id4-/-) on adult prostate morphology. Methods: Histological analysis was performed on prostates from 6-8 weeks old Id4-/-, Id4+/- and Id4+/+ mice. Expression of Id1, Sox9, Myc, androgen receptor, Akt, p-Akt, Pten and Nkx3.1 was investigated by immunohistochemistry. Androgen receptor binding on NKX3.1 promoter was studied by chromatin immuno-precipitation. Id4 was either over-expressed or silenced in prostate cancer cell lines DU145 and LNCaP respectively followed by analysis of PTEN, NKX3.1 and Sox9 expression

Vascular Complications of Pancreatitis: Role of Interventional Therapy

Major vascular complications related to pancreatitis can cause life-threatening hemorrhage and have to be dealt with as an emergency, utilizing a multidisciplinary approach of angiography, endoscopy or surgery. These may occur secondary to direct vascular injuries, which result in the formation of splanchnic pseudoaneurysms, gastrointestinal etiologies such as peptic ulcer disease and gastroesophageal varices, and post-operative bleeding related to pancreatic surgery. In this review article, we discuss the pathophysiologic mechanisms, diagnostic modalities, and treatment of pancreatic vascular complications, with a focus on the role of minimally-invasive interventional therapies such as angioembolization, endovascular stenting, and ultrasound-guided percutaneous thrombin injection in their management

Optogenetic Activation of A11 Region Increases Motor Activity

Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor function and control of pain. Here we show that the A11 region initiates movement. Photostimulation of channelrhodopsin 2 (ChR2) transfected neurons in A11 slice preparations showed that neurons could follow stimulation at frequencies of 20 Hz. Our data show that photostimulation of ChR2 transfected neurons in the A11 region enhances motor activity often leading to locomotion. Using vGluT2-reporter and vGAT-reporter mice we show that the A11 tyrosine hydroxylase positive (TH) dopaminergic neurons are vGluT2 and vGAT negative. We find that in addition to dopaminergic neurons within the A11 region, there is another neuronal subtype which expresses the monoenzymatic aromatic L-amino acid decarboxylase (AADC), but not TH, a key enzyme involved in the synthesis of catecholamines including dopamine. This monoaminergic-based motor circuit may be involved in the control of motor behavior as part of a broader diencephalic motor region

Embedding Community Voice into Smart City Spatial Planning

Public participation in spatial planning is a vital means to successful policymaking and can be enhanced by combining geospatial methods with participatory learning and action. Based on a pilot study in Bhopal, India involving urban authorities, civil society organisations and experts in an informal settlement during Covid-19 lockdowns, we find that the obstacles to sustaining public participation are not technological, but arise from a lack of awareness of the added value of ‘second order solutions’. We outline key approaches that emphasise short-term, feasible, and low-cost ways to embed community voice into participatory spatial planning.European Unio